Approach 1: Limiting who can use a tool ... and how
There are several things we can do that make malicious use much less likely. One obvious, simple, and effective approach is to carefully vet those who can use a tool. This is what companies like Synthesia are doing—essentially, working only with vetted enterprise clients.
An alternative is to constrain usage: to limit what users can synthesize or manipulate.
Approach 2: Discouraging malicious use
For synthetic media tools that are general and may be made widely available, there are still many possible ways to reduce malicious use.